Pentapharm

( Health, Nutrition & Bioscience )

Pentapharm Product List

Product	Chemical Formula	Properties	Article No.
Substrate for Thrombin
Pefachrome® TH 5244	Tos-Gly-Pro-Arg-pNA · AcOH	Km (human Thrombin) 25.60 µM Km (bovine Thrombin) 34.63 µM	081-01
		Vmax (human Thrombin) 0.80 µM/min Vmax (bovine Thrombin) 0.97 µM/min
		Kcat (human Thrombin) 978.62 min-1 Kcat (bovine Thrombin) 1185.16 min-1
Pefachrome® TH	H-D-CHG-Ala-Arg-pNA · 2AcOH	n.a	081-03
Pefachrome® TH 5247	H-D-CHG-But-Arg-pNA · 2AcOH	n.a.	081-05
Pefachrome® TH 5251	H-D-CHA-Ala-Arg-pNA · 2AcOH	Km (human Thrombin) 20.34 µM Km (bovine Thrombin) 42.11 µM	081-09
		Vmax (human Thrombin) 0.72 µM/min Vmax (bovine Thrombin) 1.18 µM/min
		Kcat (human Thrombin) 882.86 min-1 Kcat (bovine Thrombin) 1447.42 min-1
Pefachrome® FXIIa/TH 5253	H-D-CHA-Gly-Arg-pNA · 2AcOH	Km (human Thrombin) 49.80 µM Km (bovine Thrombin) 78.66 µM	081-11
		Vmax (human Thrombin) 1.23 µM/min Vmax (bovine Thrombin) 1.60 µM/min
		Kcat (human Thrombin) 1503.49 min-1 Kcat (bovine Thrombin) 1954.58 min-1
Pefachrome® TH 5256	CH3OCO-Gly-Pro-Arg-pNA · AcOH	Km (human Thrombin) 44.84 µM Km (bovine Thrombin) 38.62 µM	081-15
		Vmax (human Thrombin) 0.04 µM/min Vmax (bovine Thrombin) 0.04 µM/min
		Kcat (human Thrombin) 53.99 min-1 Kcat (bovine Thrombin) 48.90 min-1
Pefachrome® TH 8198 (corresp. S-2238)	H-D-Phe-Pip-Arg-pNA · 2HCl	Km (human Thrombin) 14.36 µM Km (bovine Thrombin) 22.81 µM	081-66
		Vmax (human Thrombin) 0.67 µM/min Vmax (bovine Thrombin) 0.74 µM/min
		Kcat (human Thrombin) 823.53 min-1 Kcat (bovine Thrombin) 909.61 min-1
Pefachrome® TH 1206	H-Sar-Pro-Arg-pNA · 2HCl	Km (human Thrombin) 43.33 µM Km (bovine Thrombin) 93.80 µM	801206
		Vmax (human Thrombin) 0.12 µM/min Vmax (bovine Thrombin) 0.15 µM/min
		Kcat (human Thrombin) 149.45 min-1 Kcat (bovine Thrombin) 188.94 min-1
Substrate for the determination of Thrombin generation
Pefachrome® TG	H-ß-Ala-Gly-Arg-pNA · 2AcOH	Km 1.95 µM\nKcat 1.91 s-1	081-17
Substrate for Urokinase
Pefachrome® uPA 8294 (corresp. S-2444)	Pyroglu-Gly-Arg-pNA · HCl	Km 6 µM\nVmax 1.3 10-10 µM/min	082-33
Substrate for Plasmin
Pefachrome® PL/Tryp 5261	Tos-Gly-Pro-Lys-pNA · AcOH	n.a.	083-01
Pefachrome® PL 5262	H-D-But-CHA-Lys-pNA · 2AcOH	n.a.	083-02
Pefachrome® PL 5263	H-D-Nva-CHA-Lys-pNA · 2AcOH	n.a.	083-03
Pefachrome® PL 5264	H-D-Nle-CHA-Lys-pNA · 2AcOH	n.a.	083-04
Pefachrome® PL 5272	H-D-Nle-CHA-Lys-pNA · 2HCI	n.a.	083-14
Substrate for Trypsin
Pefachrome® TRY 5274	Cbo-Val-Gly-Arg-pNA · AcOH	Km 0.181 µM\nVmax 43.3 µM/min	084-01
Pefachrome® 6047 (BAPNA)	Bz-DL-Arg-pNA · AcOH	n.a.	090-07
Substrate for Tryptase
Pefachrome® PL/Tryp 5261	Tos-Gly-Pro-Lys-pNA · AcOH	n.a.	083-01
Substrate for the determination of bacteria endotoxins
Pefachrome® FXa/LAL 5288	CH3OCO-D-CHA-Gly-Arg-pNA · AcOH	n.a.	085-06
Pefachrome® LAL 5288	CH3OCO-D-CHA-Gly-Arg-pNA	n.a.	086-11
Pefachrome® LAL 2423	Ac-Ile-Glu-Gly-Arg-pNA · TFA	n.a.	801741
Pefachrome® LAL 2834	Ac-Ile-Glu-Gly-Lys-pNA · TFA	n.a.	802143
Substrate for C1-esterase
Pefachrome® C1E 5292	C2H5CO-Lys(Cbo)-Gly-Arg-pNA · AcOH	n.a.	087-01
Pefachrome® C1E 5603	CH3CO-Lys(Cbo)-Gly-Arg-pNA · AcOH	n.a.	087-03
Substrate for activated protein C
Pefachrome® PCa	H-D-Lys(Cbo)-Pro-Arg-pNA · 2AcOH	Km 0.303 µM\nVmax 25 µmol/ml Protein C/min	089-02
Pefachrome® PCa 5297	Pad-Pro-Arg-pNA · AcOH	n.a.	089-07
Substrate for tPA
Pefachrome® tPA	CH3SO2-D-CHA-Gly-Arg-pNA · AcOH	Km sc-tPA 0.286 µM Km tc-tPA 0.167 µM	091-01
		Vmax sc-tPA 6.95 µmol/µg tPA/min Vmax tc-tPA 33.9 µmol/µg tPA/min
Pefachrome® tPA 5312	CH3SO2-D-Phe-Gly-Arg-pNA · AcOH	n.a.	091-03
Substrate for Factor VIIa
Pefachrome® FVIIa	CH3SO2-D-CHA-But-Arg-pNA · AcOH	Km (without TF) 5.0 µM\nKm (with TF:Ratio VIIa / TF:≈1/10) 0.97 µM	093-01
		Vmax (without TF) 6.72 µmol/min\nVmax (with TF:Ratio VIIa / TF:≈1/10) 69.7 µmol/min
Substrate for Factor IXa
Pefachrome® FIXa	CH3SO2-D-CHG-Gly-Arg-pNA · AcOH	Km 1.3 µM\nKcat 4.4 s-1	095-20
Substrate for Factor XIa
Pefachrome® FXIa	Z-Aad-Pro-Arg-pNA · AcOH	Km 0.266 µM\nVmax 5.7 µM/min	090-41
Substrate for Factor Xa
Pefachrome® FXa 5277	CH3SO2-D-Leu-Gly-Arg-pNA · AcOH	Km (human FXa) 233 µM\nKm (bovine Thrombin) 154 µM	085-01
		Vmax (human FXa) 0.736 µM/min Vmax (bovine FXa) 0.141 µM/min
		Kcat (human FXa) 5643 min-1 Kcat (bovine FXa) 1080 min-1
Pefachrome® FXa 5279	CH3OCO-D-CHG-Gly-Arg-pNA · AcOH	Km (human FXa) 97 µM Km (bovine FXa) 118 µM	085-03
		Vmax (human FXa) 0.598 µM/min Vmax (bovine FXa) 0.149 µM/min
		Kcat (human FXa) 4589 min-1 Kcat (bovine FXa) 1145 min-1
Pefachrome® FXa/LAL 5288	CH3OCO-D-CHA-Gly-Arg-pNA · AcOH	Km (human FXa) 164 µM Km (bovine FXa) 168 µM	085-06
		Vmax (human FXa) 0.937 µM/min Vmax (bovine FXa) 0.190 µM/min
		Kcat (human FXa) 7148 min-1 Kcat (bovine FXa) 1455 min-1
Pefachrome® FXa 8595 (corresp. S-2765)	Z-D-Arg-Gly-Arg-pNA · 2HCl	Km (human FXa) 60 µM Km (bovine FXa) 103 µM	085-27
		Vmax (human FXa) 0.710 µM/min Vmax (bovine FXa) 0.315 µM/min
		Kcat (human FXa) 5441 min-1 Kcat (bovine FXa) 2481 min-1
Substrate for Factor Xa (continued…)
Pefachrome® FXa 5278	CH3OCO-D-Nle-Gly-Arg-pNA · AcOH	n.a	085-50
Pefachrome® FXa 2732 (corresp. S-2732)	Suc-Ile-Glu(gamma-Pip)-Gly-Arg-pNA · HCl	Km (human FXa) 176 µM Km (bovine FXa) 163 µM	802893
		Vmax (human FXa) 0.779 µM/min Vmax (bovine FXa) 0.134 µM/min
		Kcat (human FXa) 5976 min-1 Kcat (bovine FXa) 1028 min-1
Substrate for Factor XIIa
Pefachrome® FXIIa/TH 5253	H-D-CHA-Gly-Arg-pNA · 2AcOH		081-11
Pefachrome® 6017	H-D-CHA-Gly-Arg-pNA · 2AcOH		081-45
Substrate for plasma kallikrein
Pefachrome® PK6001	Bz-Pro-Phe-Arg-pNA · AcOH	n.a	080-01
Pefachrome® PK	H-D-But-CHA-Arg-pNA · 2AcOH	Km 0.175 µM\nVmax 7.48 µM/min	080-03

Product	Chemical Formula	Properties	Article No.
Amperogenic Thrombin substrate	Tos-Gly-Pro-Arg-4-Amido-2-Chloro-Phenol · AcOH	Vial 25 mg	602-01

Product	Chemical Formula	Properties	Article No.
Substrate for Thrombin
Pefafluor® TH	Z-Gly-Gly-Arg-AMC · HCl	Vial 25 mg	801058
Pefafluor® TH	H-D-CHA-Ala-Arg-AMC · 2AcOH	Vial 25 mg	081-19
Substrate for Factor Xa
Pefafluor® FXa	CH3SO2-D-CHA-Gly-Arg-AMC · AcOH	Vial 25 mg	085-12
Substrate for the determination of bacterial endotoxins
Pefafluor® LAL 5291	CH3SO2-D-CHA-Gly-Arg-AMC · AcOH	Vial 25 mg	086-04
Substrate for activated protein C
Pefafluor® PCa	Pyroglu-Pro-Arg-AMC · AcOH	Vial 25 mg	089-05
Substrate for tPA
Pefafluor® tPA	CH3SO2-D-Phe-Gly-Arg-AMC · AcOH	Vial 25 mg	091-06
Substrate for Factor IXa
Pefafluor® FIXa	CH3SO2-D-CHG-Gly-Arg-AMC · AcOH	Vial 25 mg	095-03

Product	Properties	Article No.
Prionex® 10%	Bottles 100 ml, 500 ml, 1’000 ml	069-03
Prionex® Pellets	Vial 1g, 5g	802943

Product			Packging Unit
RB Cephalin, freeze dried	Vial 100 mg, 1g	801682	Vial 100 mg, 1g

Product	Chemical Formula	Properties	Article No.
Inhibits serine proteases
Aprotinin Conc. Solution	n.a.	Vial 50 ml, 1’000 ml	073-70
Aprotinin Powder, lyoph.	n.a.	Vial 1 g (ca. 6 Mio.KIU)	800277
Pefabloc® SC	C8-H10FNO2S · HCI	Vial 1 g, 10 g	399-01
Inhibits fibrin polymerization
Pefabloc® FG	H-Gly-Pro-Arg-Pro-OH · AcOH	Vial 50 mg, 1 g	099-01
Inhibits plasma kallikrein
Pefabloc® PK	C24-H26N4O3S · HCI	1 mg	380-03
Inhibits Thrombin
Pefabloc® TH (α-NAPAP)	C27-H31N5O4S · AcOH	Vial 5 mg	381-01
r-Hirudin EC	n.a.	Vial 2000 ATU	126-10
r-Hirudin	n.a.	Vial 2000 ATU	126-11

For the determination of fibrinogen

Product	Packging Unit	Article No.
Batroxobin maranhao	Vial 100 BU	101-04
Batroxobin maranhao	Vial 1’000 BU	101-06

Fast acting protein C activator

Product	Packging Unit	Article No.
Protac®	Vial 3 U	113-01
Protac® lyophilized Bulk	Vial 500 U, 1’000 U	113-04
Protac® solution	Bulk 10 U/ml	113-05

For the determination of prothrombin and hirudin, specifically activates prothrombin via meizothrombine

Product	Packging Unit	Article No.
Ecarin	Vial 50 EU	116-01

For activation of human platelets via GPVI-receptor, studies on platelets receptors

Product	Packging Unit	Article No.
Convulxin	Vial 50 µg	119-02

For activation and determination of Factor V

Product	Packging Unit	Article No.
RVV Factor V-Activator	Vial 1’000 U	121-03

For the determination of Factor X and for screening of Lupus Anticoagulants

Product	Packging Unit	Article No.
RVV Factor X-Activator	Vial 5 U	121-06
RVV Factor X-Activator	Vial 50 U	121-07

Product	Packging Unit	Article No.
Pefakit® APC-R Factor V Leiden	3 x 2 ml APC/RVV-V (+APC) Reagent 3 x 2 ml RVV-V (-APC) Reagent 3 x 4 ml PTA Reagent 3 x 2 ml Dilution Plasma	502-01; for US 502-02
Pefakit® APC-R Factor V Leiden Controls	3 x 1 ml FV-L Negative Control 3 x 1 ml FV-L Heterozygous Control	502-21; for US 502-22

“Pefaclot™ UFH is a plasma based functional assay for the determination of unfractionated heparin (UFH).

Product	Packging Unit	Article No.
Pefaclot™ UFH	3 x 2 ml Activator 3 x 2 ml Start Reagent	505-50
Pefaclot™ UFH Controls	3 x 1 ml Control UFH 1 3 x 1 ml Control UFH 2	505-60

For the investigation of the last phase of blood coagulation. Due to its heparin insensitivity, the Reptilase® Time can detect fibrinogen polymerization disorders even in the presence of heparin.

Product	Packging Unit	Article No.
Pefakit® Reptilase® Time	3 x 1 ml Reptilase Time Reagent	800191

Product	Packging Unit	Article No.
Pefakit® TAFI	2 x 4 ml Activator 2 x 4 ml Start Reagent 2 x 4 ml Diluent	800186
Pefakit® TAFI Calibrator and Controls	1 x 1 ml Calibrator 1 x 1 ml Control 1 1 x 1 ml Control 2	800187

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Pentapharm

Pentapharm Product List

For the determination of fibrinogen

Fast acting protein C activator

For the determination of prothrombin and hirudin, specifically activates prothrombin via meizothrombine

For activation of human platelets via GPVI-receptor, studies on platelets receptors

For activation and determination of Factor V

For the determination of Factor X and for screening of Lupus Anticoagulants

“Pefaclot™ UFH is a plasma based functional assay for the determination of unfractionated heparin (UFH).

For the investigation of the last phase of blood coagulation. Due to its heparin insensitivity, the Reptilase® Time can detect fibrinogen polymerization disorders even in the presence of heparin.

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